![]() Photocatalysis in Chemical Biology: Extending the Scope of Optochemical Control and Towards New Frontiers in Semisynthetic Bioconjugates and Biocatalysis. Potent Trivalent Inhibitors of Thrombin through Hybridization of Salivary Sulfopeptides from Hematophagous Arthropods. Rücktitelbild: Potent Trivalent Inhibitors of Thrombin through Hybridization of Salivary Sulfopeptides from Hematophagous Arthropods (Angew. Angewandte Chemie International Edition, 60(10), 5570.Īgten, S. Back Cover: Potent Trivalent Inhibitors of Thrombin through Hybridization of Salivary Sulfopeptides from Hematophagous Arthropods (Angew. Journal of the American Chemical Society, 143(12), 4467-4482.Īgten, S. Biosupramolecular Systems: Integrating Cues into Responses. Angewandte Chemie International Edition, 61(28). Cover Picture: Optochemical Control of Therapeutic Agents through Photocatalyzed Isomerization (Angew. E., Russo, F., Moreau, D., & Winssinger, N. Current Opinion in Chemical Biology, 66, 8 pages. Biosupramolecular networks: Taking inspiration from nature to create powerful synthetic platforms. C., Niederacher, G., Johansen‐Leete, J., Huhmann, S. ![]() ![]() Titelbild: Optochemical Control of Therapeutic Agents through Photocatalyzed Isomerization (Angew. Optochemical Control of Therapeutic Agents through Photocatalyzed Isomerization. Angewandte Chemie - International Edition, 61(28), 8 pages. Site-selective photocatalytic functionalization of peptides and proteins at selenocysteine. Synthesis of Protein-Oligonucleotide Conjugates. These systems are underpinned by a combination of organic synthesis, solid phase peptide and nucleic acid synthesis, photocatalysis and bioconjugation to create final functional systems. My research focuses on using biomolecules (peptides, proteins, nucleic acids) as the key components in such responsive systems. Much like a computer, these components can be wired together to form a functional system, with the individual parts able to be swapped in and out in a modular manner to rapidly create new systems, capable of targeting new problems. release a drug) and the circuitry (this is the part that connects the inputs and the outputs, helping to transfer the information). Such systems have three key components: the inputs (this is the part capable of binding to a target molecule or sensing a change), the outputs (this is the part that does something in response to this new information i.e. By developing smart drugs and therapeutic agents capable of this type of molecular logic we can help improve their selectivity, and therefore reduce toxicity. One of the fundamental principles of life is being able to sense and respond to changes in the environment.
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